Henrik Druid

Henrik Druid
Department of Oncology-Pathology
This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

Determination of age and pathologies of human tissues

A strategy to collect and process postmortem tissue samples from deceased donors for research purposes has been established in collaboration with the department of forensic medicine. This allows for the use of human tissue in The Human Regenerative Map project. Our groups is interested in the use of bomb-pulse derived radiocarbon analysis for age determination of unidentified dead victims. We have also developed a strategy to combine 14C analysis with determination of the levels of 13C, aspartic acid enantiomere analysis and genetic profiling, which can provide information about geographical origin, year of death and sex, respectively, facilitating identification casework. Efforts are also put into studies to unravel the mechanisms behind neurogenesis, and factors that influence this process, particularly various drugs of abuse. To this end, radiocarbon analyses will be combined with neuropharmacological methods in order to relate abnormal turnover of neurons and glial cells in hippocampus with alterations due to long term and short term drug exposure.

5 Selected publications:

Alkass K, Buchholz BA, Druid H, Spalding KL. Analysis of 14C and 13C in teeth provides precise birth dating and clues to geographical origin. Forensic Sci Int. 2011 Jan 3. [Epub ahead of print]

Alkass K, Buchholz BA, Ohtani S, Yamamoto T, Druid H, Spalding KL. Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis. Mol Cell Proteomics. 2010 May;9(5):1022-30.

Mash DC, Duque L, Pablo J, Qin Y, Adi N, Hearn WL, Hyma BA, Karch SB, Druid H, Wetli CV. Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic Sci Int. 2009 Sep 10;190(1-3):e13-9.

Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyocyte renewal in humans. Science. 2009 Apr 3;324(5923):98-102.

Spalding KL, Buchholz BA, Bergman LE, Druid H, Frisén J. Forensics: age written in teeth by nuclear tests. Nature. 2005;437(7057):333-4.